Topogyne is the only registered misoprostol in Bulgaria with two indications - Termination of pregnancy up to 49 days of amenorrhea, following sequential administration with mifepristone and cervical ripening before surgical abortion.
Off-label, Topogyne is widely used in gynecological practice for labor induction, postpartum hemorrhage, and other indications, but at different doses.
As part of the approved Risk Management Plan for Topogyne, it is distributed with Training Materials for Specialists and Training Materials for Patients, including a Safety Card, which must be reviewed by all doctors and women using the medication.